A Mis-Diagnosis Plus Ice Cream Equals One Mega Sized Gut!

If Only He Knew His Lactose Gene Result!

Mighty mouse lives... well genetically created that is!

Well actually, Mighty Mouse was genetically created by Professor Richard Hanson in Cleveland a few years ago! Professor Hanson studied the role of the cytosolic form of phosphoenolpyruvate carboxykinase (PEPCK-C) in skeletal muscle. PEPCK-Cmus mice were created by introducing the cDNA for the enzyme, linked to the human alpha-skeletal actin gene promoter, into their germ line

STOP! You’ve Been Mis-Informed About Insulin Yet Again!

Busting one set of insulin myths clearly wasn’t enough for our fitness expert Mark Gilbert, so he’s returned to lift the lid on a second set of rumours surrounding the peptide hormone.

Genes and Drug Testing

What if we told you that a significant number of people have a certain gene type (a version of an ‘insertion/deletion’ genotype) that would allow them to beat a drug test? Well, it’s true!...

Using genetics to find future Olympians… Was this inevitable?

We have long known that people would start to become curious about the potential to use genetics testing to identify genetically gifted youngsters who could be nurtured as potential Olympians...

Natural Athletic Ability of African Americans

Here at FitnessGenes™, it’s the detail of theories that interests us, and we believe this is a phenomenal example of philosophy, hypothesis, and science. But first, a little history.

Collections of genes and how they allow an organism to adapt to different diets

This is a really interesting piece of research published this month in Cell Metabolism. Sean Curran and Shanshan Pang identify a collection of genes that allow an organism to adapt to different diets and show that, without them, even minor tweaks to diet can cause premature ageing and death.

“This structure has novel features which are of considerable biological interest”

In April 1953, this sentence appeared in the scientific paper where James Watson and Francis Crick presented the structure of the DNA helix, the molecule that carries genetic information from one generation to the other: that is the discovery of DNA!

Epigenetics-with-Dr-Samantha-Decombel

FitnessGenes CSO Dr Samantha Decombel discusses the topic of Epigenetics, and explains why it is vital to consider their impact when constructing your genetic profile.

6 Genes That Influence Your Training and Nutrition

There are the physiques we’re born with, there are the physiques we create, and understanding your genetics can help you get the physique you want. Here’s an overview of 6 of the 41 genes we analyse and examples of how greater understanding of your genetics can influence your lifestyle and training for better results.

Vitamin-D

Vitamin D has been a hot topic of conversation this week as leading health organisations recommended that many of us need to increase our intake to maintain healthy levels. But is your genotype putting you at an increased risk of vitamin D deficiency? Read this week's blog post to learn the vitamin's function, how it can affect physical performance, and how you can be sure you're getting enough.

Breaking genetics news on sprint and power performance

Here at FitnessGenes, we always want to keep you and our scientific analysis up-to-date! Following the release of recent research, we have updated our ACVR1B gene report. Could this mean good news for you and your power performance?

Why do Jamaicans dominate sprinting and East Africans dominate distance running?

In most sports, there are typically one or two nations that are synonymous with success: New Zealand with Rugby; Germany or Brazil in football; the USA in basketball, baseball, and American football. Team sports are difficult to analyze from a genetics perspective. Running however, is a pure and natural sport. So given the incredibly low barrier to entry in running, global competition should really be fierce…..except it’s not.

Are You Genetically More Like Your Mother or Your Father?

You may have your mother’s eyes or your father’s math skills, but how do your parents really influence your genetic makeup? Our Science Team explains.

Subcutaneous vs Visceral fat. Which do you carry?

Get to know your key exercise organ: The anatomy of the heart

Will you experience menopause the same as your mother?

Menopause is not exactly a life event that women look forward to. We look at the genetic factors that can influence the physical and psychological symptoms of this transitional stage in women’s lives.

The Obesity Paradox

The easy availability of cheap, calorie-dense, but nutrient poor foods is simultaneously over feeding and under nourishing the developed, and developing worlds.

Food cravings

What’s behind your insatiable desire for chocolate? And what, if anything, can you do about it? Managing your food cravings.

Is gene doping the future of cheating?

What exactly is gene doping, what are the dangers, and should you suspect your fellow competitors or admired elite athletes have been genetically enhanced anytime soon?

Enteric Nervous System

What is the Enteric Nervous System, and how does it interact with your gut bacteria and brain?

How your sleep cycle impacts your weight and your workouts

Are you a morning lark or a night owl? We’ll help you understand your body clock and how it affects weight loss and your performance in the gym.

What's the difference between fast and slow twitch muscle fibers?

There are 3 different types of skeletal muscle fiber in the human body. We explain the differences and how genetics and training influence muscle composition

Unraveling the secrets of our circadian rhythm

Your CLOCK gene can tell you whether you’re more likely to be a night owl or morning lark, or advise you on when best to work out, eat, or drink coffee.

How finger length influences overall strength

Testosterone in the womb determines the ratio of your index and ring fingers, which directly influences your predisposition for lean muscle and strength gains

Is struggling with weight your destiny?

Are you overweight because of your genes, your lifestyle or both? FitnessGenes investigates the latest science in the battle against obesity.

How much coffee should I drink?

British researchers scoured 218 meta-analyses, looking at the relationship between coffee consumption (not caffeine) and various disease outcomes. We analyze the results and make our recommendations.

What do elite athletes think about DNA analysis?

According to a recent university study, the majority of elite sports people and their support professionals want to know whether DNA affects performance, changes the risk of injury, and can provide other advantageous insights into gaining a winning margin.

More exercise burns fewer calories? You can't be serious?

One of the benefits of getting fitter is that workouts start to feel easier. Does this mean you now burn fewer calories when exercising? We explain the science.

Does exercise make you happier?

Does exercise make you happier or do happier people exercise more? FitnessGenes science team investigates the latest research and explains the optimal amount of exercise for maximum mental health benefit.

The Human Genome Project at 15: what have we learned?

There are 3 BILLION base pairs in the human DNA sequence, yet we're all 99.5-99.9% the same. While only 0.1% - 0.4% of our genome varies between individuals, we are all significantly different. We look different to each other, we behave differently, and we respond differently to diet and exercise.

5 ways to make healthy changes in your life

NOT your typical clickbait social media post, this is a scientific view of how you can make positive changes in your life that will benefit your health and fitness

The benefits of a weekend lie-in

Lack of sleep has proven health risks. Oversleeping also carries risks. What is the correct amount of sleep and can you "catch up" on lost sleep? We investigate the latest research

Working out with PCOS

PCOS (Polycystic Ovarian Syndrome) is common in the general population, affecting 5-10% of women and it is particularly prevalent in female athletes. We investigate the genetic and lifestyle issues for women with this condition.

Genetics of elite footballers

Elite football players are gifted sportspeople. Find out which genes might predetermine some players for greatness. We explain the research into the genetics of elite footballers

Homocysteine and your folate genes explained

Homocysteine has become a buzzword of late in the medical world. New evidence is published monthly highlighting this amino acid as a substantial risk factor in the development of cardiovascular disease and dementia. We take a closer look at this important molecule, highlighting reasons to be aware of it, and what can be done to minimize its potentially harmful effects. Read more

Is too much exercise bad for your mental health?

We all know that exercise brings many mental health benefits, including improved mood, relief from stress, and a reduced risk of mental illness. But is there an ideal amount of exercise for our mind? Our science team looks at the findings of an interesting new study.

Is obesity all in the brain?

Is obesity caused by poor diet and lack of exercise, or by the way you're wired? With 75% of obesity-related genes chiefly expressed in the brain, the latest research is truly fascinating.

Pillow talk-The importance of sleep for recovery and performance

Sleep should be the foundation of your healthy lifestyle. We explain the science and offer tips to help you get a better night's sleep

Can exercise alter your gut bacteria?

Around 100 trillion bacteria, viruses and fungi are all living happily in your gut, helping to digest food, produce vitamins and maintain immune function. We know that changes in our diet can alter the composition of these microorganisms in our gut, which in turn can have major effects on our health and fitness. But what about exercise? Can that alter our gut bacteria? Our science team takes a closer look.

Are you salt sensitive?

Nearly of quarter of people are sensitive to salt, meaning their blood pressure rises excessively in response to sodium in their diet. We explain the fascinating science behind this phenomenon.

Choline Explained

If you’re a FitnessGenes customer, you’ll know that one of your Personal Insights concerns your requirement for choline. So, just what is choline, why does your body need it, and where can you get it from? This article explains everything you need to know.

Is 'yo-yo' weight cycling bad for me?

A new study shows that weight cycling, which refers to extreme fluctuations in bodyweight, increases the risk of death. Our science team takes a deeper look at the research.

Are you sure you have a food allergy?

According to a new study, too many of us are responding ‘yes’ when posed this question. That is, several people incorrectly think they have an allergy. The study, published in the journal JAMA Open Network, found that around 1 in 5 people in the US believe they have a food allergy. In reality, far fewer (closer to 1 in 10) people actually suffer from a true allergy. Many of these people instead experience symptoms better described by the term ‘food intolerance.’ So, just what is an allergy? And how is it different from a food intolerance?

Should I take the stairs?

According to a new study, taking the stairs in short bouts leads to better aerobic fitness and muscle strength.

Are American Football Players Obese?

The Superbowl is this weekend and NFL fans are likely to be treated to a veritable feast of sporting prowess. But, did you know that the overwhelming majority of elite American Football players are in fact overweight or obese?

5 effects of exercise on your heart

We all know that “exercise is good for the heart” – but, what exactly does this mean? In celebration of National Heart Month (and, perhaps somewhat spuriously, Valentine’s day), we explore some of the changes your heart undergoes in response to regular, vigorous exercise.

How many push ups can you do?

It’s one of the simplest yet most effective bodyweight exercises around: the humble push-up (or press up). A staple of high-school gym class, military training and HIIT workouts, the push-up engages several muscle groups, including the pectorals, deltoids, triceps and core muscles. According to new research, push-ups may also be particularly good for your heart.

Nitric Oxide and Blood Flow

All you need to know about nitric oxide and blood flow, including how to increase blood flow to exercising muscles.

Your Renin-Angiotensin-Aldosterone System and why it's important

All you need to know about your Renin-Angiotensin-Aldosterone System, a complex system of hormones that controls your blood pressure, blood volume and blood flow.

BH4 Synthesis and Recycling

All you need to know about your two BH4 traits that affect blood flow and the formation of neurotransmitters.

Testosterone Levels

All you need to know about your testosterone traits.

Estrogen production

All you need to know about your estrogen production trait.

Insulin and your blood glucose levels

All you need to know about your blood glucose level trait.

Night-time glucose regulation (melatonin)

All you need to know about your insulin, melatonin and sleep trait.

Serum Calcium Level

All you need to know about your serum calcium level trait.

Sex hormones, visceral fat, and insulin

All you need to know about your Sex hormones, Visceral fat and Insulin Trait.

Vascular Smooth Muscle Contraction

All you need to know about your vascular smooth muscle contraction trait.

Optimizing cortisol for exercise and recovery

All you need to know about your Cortisol Trait.

Leptin resistance

All you need to know about your Leptin Resistance trait.

Adrenaline: Baseline Level

All you need to know about your Adrenaline: Baseline Level trait.

Adrenaline: Acute Response

All you need to know about your Adrenaline: Acute Response trait.

Dopamine Metabolism

All you need to know about your Dopamine Metabolism trait.

Dopamine metabolism II - MAO

An introduction to your Dopamine Metabolism II - MAO activity.

Serotonin Synthesis

Serotonin (also known as 5-HT) is often dubbed our “happiness hormone.” It is a neurotransmitter (i.e. a nerve communication molecule) involved in the regulation of our mood and emotions, including feelings of anxiety, surprise and happiness. Brain circuits that use serotonin also control our sleep pattern, food intake, processing of pain, and so-called ‘cognitive’ functions, such as attention, memory, decision-making and problem solving. Serotonin’s actions are not just restricted to the brain, it plays an important role in our enteric nervous system – the network of nerves that controls the function of our gut. In addition to acting as neurotransmitter, serotonin also acts as a hormone – a chemical signal that is transported in the bloodstream. Cells lining our digestive system produce serotonin, which then enters the bloodstream, where it has an effect on blood clotting, wound healing and blood flow. To find out more this and other personalized traits, login to truefeed or sign up for a FREE truefeed account.

Mitochondrial Biogenesis (PGC-1α)

“Mitochondria are the powerhouses of the cell” You may remember that neat phrase from high school biology class. Our mitochondria (single = mitochondrion) are specialized structures or “organelles” within our cells that are responsible for producing energy. More specifically, mitochondria carry out cell respiration - the process by which we convert chemical energy from food into a common energy currency that can be used to power all sorts of cellular functions. Such cellular functions include the transport of molecules, growth of new cells and the contraction of muscle fibers, all of which require an energy currency molecule called adenosine tri-phosphate or ATP. This trait looks at how well your muscles grow and generate new mitochondria. This process, called mitochondrial biogenesis, plays a major role in exercise (particularly endurance / aerobic exercise) performance.

Protein Synthesis and Hypertrophy (mTOR)

mTOR stands for Mammalian Target of Rapamycin. It is a key molecule that regulates the growth of cells in response to various stimuli, including: the availability of nutrients, changes in energy balance, hormones, changes in blood flow and oxygen delivery, and mechanical load on muscles (e.g. as part of resistance training). mTOR controls the growth and production (or ‘synthesis’) of protein in various types of cells, including muscle cells (muscle fibers). Enlargement of muscle fibers (hypertophy) relies upon mTOR signalling. It therefore plays an important role in muscle gains following exercise. mTOR also regulates a process called autophagy - the breakdown and recycling of old, faulty and damaged cell components. This process helps to rejuvenate cells and influences how quickly our cells age. mTOR is therefore crucially involved in the ageing process.

Metabolic Efficiency and UCP1

Metabolic Efficiency and Fuel Usage (UCP2)

Fat metabolism (beta oxidation)

IGF-1 and muscle growth

ACTN3 and Muscle Performance

FTO and obesity risk

Choline Synthesis and Metabolism

Betaine Synthesis and Metabolism

IL-6 and Inflammation

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